Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 5/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.33 |
| ▸ | ANXA2 | P07355 | 1/20 | 0.33 |
| ▸ | S100A10 | P60903 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL581628 | 0.97 | EPHX2 (0.44) | EPHX2CYP11B1CYP11B2ALDH1A1KDM4E | |
| SCHEMBL580803 | 0.89 | NOTUM (0.42) | EPHX2NOTUMKDM1ATRPM8 | |
| SCHEMBL581321 | 0.89 | EPHX2 (0.37) | EPHX2CYP11B1CYP11B2ALDH1A1KDM4E | |
| SCHEMBL581320 | 0.89 | EPHX2 (0.37) | EPHX2CYP11B1CYP11B2ALDH1A1KDM4E | |
| SCHEMBL3080499 | 0.89 | EPHX2 (0.37) | EPHX2CYP11B1CYP11B2ALDH1A1KDM4E | |
| SCHEMBL581727 | 0.87 | NOTUM (0.38) | ALDH1A1KDM4ENOTUMTDP1 | |
| SCHEMBL581726 | 0.87 | NOTUM (0.38) | ALDH1A1KDM4ENOTUMTDP1 | |
| SCHEMBL3072590 | 0.86 | ALDH1A1 (0.43) | ALDH1A1KDM4ETDP1 | |
| SCHEMBL3072798 | 0.86 | ALDH1A1 (0.43) | ALDH1A1KDM4ETDP1 | |
| SCHEMBL580838 | 0.86 | ALDH1A1 (0.43) | ALDH1A1KDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417131-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | AstraZeneca AB (SE) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010117323-A1 | METHOD AND APPARATUS FOR PRODUCING HEAT ENERGY AND CARBON DIOXIDE | ASTRAZENECA AB (SE) | 2010-10-14 | — | — | WO | disclosed |