Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.40 |
| ▸ | RGS12 | O14924 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 4/20 | 0.39 |
| ▸ | BRAF | P15056 | 2/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | TEK | Q02763 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5820626 | 0.99 | AURKA (0.43) | AURKAAURKBRETCYP1A2TSHR | |
| SCHEMBL5821773 | 0.97 | AURKA (0.45) | AURKAAURKBRETCYP1A2TSHR | |
| SCHEMBL5823053 | 0.91 | AURKA (0.45) | AURKAAURKBRETCYP1A2MAPT | |
| SCHEMBL5824056 | 0.89 | AURKA (0.48) | AURKAAURKBRETCYP1A2MAPT | |
| SCHEMBL5815015 | 0.87 | AURKA (0.47) | AURKAAURKBRETCYP1A2MAPT | |
| SCHEMBL5823423 | 0.87 | AURKA (0.46) | AURKAAURKBRETCYP1A2MAPT | |
| SCHEMBL5820773 | 0.87 | AURKA (0.42) | AURKAAURKBRETCYP1A2MAPT | |
| SCHEMBL5402668 | 0.85 | AURKA (0.48) | AURKAAURKBCYP1A2TP53MAPT | |
| SCHEMBL5821064 | 0.85 | SMN1; SMN2 (0.44) | AURKAAURKBCYP1A2TSHRMAPT | |
| SCHEMBL5820813 | 0.85 | NAMPT (0.47) | AURKAAURKBRETCYP1A2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006137706-A1 | 6-(4-SUBSTITUTED-ANILINO)PYRIMIDINE DERIVATIVES, METHOD FOR PREPARING THEREOF AND ANTIVIRAL PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | B & C BIOPHARM. CO., LTD. (KR) | 2006-12-28 | — | — | WO | disclosed |