Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 20/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL389289 | 0.94 | GPR119 (0.71) | GPR119CYP2C9KCNH2 | |
| SCHEMBL3156860 | 0.91 | GPR119 (0.72) | GPR119CYP2C9KCNH2 | |
| SCHEMBL3139864 | 0.89 | GPR119 (0.75) | GPR119CYP2C9KCNH2 | |
| SCHEMBL3138525 | 0.88 | GPR119 (0.72) | GPR119CYP2C9KCNH2 | |
| SCHEMBL386836 | 0.88 | GPR119 (0.72) | GPR119CYP2C9KCNH2 | |
| SCHEMBL387171 | 0.86 | GPR119 (0.69) | GPR119CYP2C9KCNH2 | |
| SCHEMBL3151965 | 0.86 | GPR119 (0.69) | GPR119CYP2C9KCNH2 | |
| SCHEMBL3152140 | 0.86 | GPR119 (0.75) | GPR119CYP2C9KCNH2 | |
| SCHEMBL3147378 | 0.86 | GPR119 (0.75) | GPR119CYP2C9KCNH2 | |
| SCHEMBL390247 | 0.86 | GPR119 (0.75) | GPR119CYP2C9KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732562-A2 | SUBSTITUTED PYRIDINYL AND PYRIMIDINYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2006-12-20 | — | — | EP | disclosed |
| WO-2006083491-A2 | SUBSTITUTED PYRIDINYL AND PYRIMIDINYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2006-08-10 | — | — | WO | disclosed |