Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.64 |
| ▸ | SRC | P12931 | 1/20 | 0.64 |
| ▸ | STK10 | O94804 | 4/20 | 0.56 |
| ▸ | SLK | Q9H2G2 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | GSK3B | P49841 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | NSD2 | O96028 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7042345 | 0.82 | MAPT (0.59) | EGFRSRCSTK10SLKMAPT | |
| SCHEMBL11878949 | 0.82 | KDM4E (0.53) | EGFRSRCSTK10SLKMAPT | |
| SCHEMBL3259553 | 0.82 | KDM4E (0.64) | EGFRSRCSTK10SLKMAPT | |
| SCHEMBL9566607 | 0.81 | KDM4E (0.51) | EGFRSRCMAPTMAPK1HSD17B10 | |
| SCHEMBL11596912 | 0.81 | MAPT (0.58) | EGFRSRCSTK10SLKMAPT | |
| SCHEMBL9657357 | 0.81 | EGFR (0.64) | EGFRSRCSTK10SLKMAPT | |
| SCHEMBL9566625 | 0.81 | KDM4E (0.51) | EGFRSRCSTK10SLKMAPT | |
| SCHEMBL133403 | 0.81 | EGFR (0.64) | EGFRSRCSTK10SLKMAPT | |
| SCHEMBL5814108 | 0.80 | EGFR (0.88) | EGFRSRCSTK10SLKMAPT | |
| Hydrochloric Acid SCHEMBL5138495 | 0.80 | KDM4E (0.62) | EGFRSRCSTK10SLKMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006047514-A2 | DAPH ANALOGS AND INHIBITION OF PROTEIN AGGREGATION | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2006-05-04 | — | — | WO | disclosed |