Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 15/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4143650 | 1.00 | HTR1A (0.52) | HTR1ASLC6A4DRD2 | |
| SCHEMBL4143142 | 1.00 | HTR1A (0.52) | HTR1ASLC6A4DRD2 | |
| SCHEMBL4137022 | 0.85 | HTR1A (0.59) | HTR1ASLC6A4 | |
| SCHEMBL5822727 | 0.85 | HTR1A (0.59) | HTR1ASLC6A4 | |
| SCHEMBL4156264 | 0.85 | HTR1A (0.59) | HTR1ASLC6A4 | |
| SCHEMBL4134169 | 0.83 | HTR1A (0.56) | HTR1A | |
| SCHEMBL4153195 | 0.83 | HTR1A (0.56) | HTR1A | |
| SCHEMBL3564266 | 0.80 | HTR1A (0.58) | HTR1ASLC6A4 | |
| SCHEMBL6642452 | 0.77 | HTR1A (0.69) | HTR1A | |
| SCHEMBL4145064 | 0.76 | HTR1A (0.48) | HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641785-A2 | BENZOFURANYL-AND BENZOTHIENYL-PIPERAZINYL QUINOLINES AS SEROTONIN REUPTAKE INHIBITORS | Wyeth (US) | 2006-04-05 | — | — | EP | claimed |
| WO-2004099191-A2 | BENZOFURANYL-AND BENZOTHIENYL-PIPERAZINYL QUINOLINES AS SEROTONIN REUPTAKE INHIB ITORS | WYETH (US) | 2004-11-18 | — | — | WO | claimed |
| EP-1641785-A2 | BENZOFURANYL-AND BENZOTHIENYL-PIPERAZINYL QUINOLINES AS SEROTONIN REUPTAKE INHIBITORS | Wyeth (US) | 2006-04-05 | — | — | EP | disclosed |
| WO-2004099191-A2 | BENZOFURANYL-AND BENZOTHIENYL-PIPERAZINYL QUINOLINES AS SEROTONIN REUPTAKE INHIB ITORS | WYETH (US) | 2004-11-18 | — | — | WO | disclosed |