Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | CCR3 | P51677 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6027066 | 0.79 | TACR1 (0.48) | CCR3HTTABCB1 | |
| SCHEMBL29283139 | 0.79 | ABCB1 (0.39) | ABCB1 | |
| SCHEMBL592356 | 0.76 | NR1H2 (0.48) | DPP4 | |
| SCHEMBL3080240 | 0.76 | TACR1 (0.43) | DPP4ABCB1 | |
| SCHEMBL24774805 | 0.75 | DAGLA (0.43) | — | |
| SCHEMBL28625821 | 0.74 | DAGLA (0.47) | — | |
| SCHEMBL29283140 | 0.73 | NPBWR1 (0.34) | HTT | |
| SCHEMBL25411772 | 0.70 | — | — | |
| SCHEMBL25409556 | 0.70 | — | — | |
| SCHEMBL22966395 | 0.70 | SLC6A2 (0.40) | ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417131-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | AstraZeneca AB (SE) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010117323-A1 | METHOD AND APPARATUS FOR PRODUCING HEAT ENERGY AND CARBON DIOXIDE | ASTRAZENECA AB (SE) | 2010-10-14 | — | — | WO | disclosed |