Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 6/20 | 0.64 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.59 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.58 |
| ▸ | MEN1 | O00255 | 8/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | PRKCA | P17252 | 1/20 | 0.45 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.45 |
| ▸ | RASGRP3 | Q8IV61 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5821802 | 1.00 | DHFR (0.64) | DHFRNTRK1MAP3K5KMT2AMEN1 | |
| SCHEMBL5807046 | 0.89 | DHFR (0.67) | DHFRNTRK1MAP3K5KMT2AMEN1 | |
| SCHEMBL5817761 | 0.89 | DHFR (0.67) | DHFRNTRK1MAP3K5KMT2AMEN1 | |
| SCHEMBL5819467 | 0.82 | DHFR (0.58) | DHFRNTRK1MAP3K5KMT2AMEN1 | |
| SCHEMBL5819471 | 0.82 | DHFR (0.58) | DHFRNTRK1MAP3K5KMT2AMEN1 | |
| SCHEMBL5482789 | 0.81 | KMT2A (0.66) | DHFRNTRK1MAP3K5KMT2AMEN1 | |
| SCHEMBL5482792 | 0.81 | KMT2A (0.66) | DHFRNTRK1MAP3K5KMT2AMEN1 | |
| SCHEMBL5476060 | 0.81 | KMT2A (0.77) | DHFRNTRK1MAP3K5KMT2AMEN1 | |
| SCHEMBL5476058 | 0.81 | KMT2A (0.77) | DHFRNTRK1MAP3K5KMT2AMEN1 | |
| SCHEMBL5822283 | 0.80 | KMT2A (0.75) | DHFRNTRK1MAP3K5KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006105796-A1 | NOVEL INDOLINONE DERIVATIVES | LEO PHARMA A/S (DK) | 2006-10-12 | — | — | WO | disclosed |