Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 19/20 | 0.49 |
| ▸ | LCK | P06239 | 5/20 | 0.44 |
| ▸ | LYN | P07948 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 5/20 | 0.42 |
| ▸ | ITK | Q08881 | 3/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | YES1 | P07947 | 1/20 | 0.41 |
| ▸ | HCK | P08631 | 1/20 | 0.41 |
| ▸ | FGR | P09769 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | FER | P16591 | 1/20 | 0.41 |
| ▸ | CSK | P41240 | 1/20 | 0.41 |
| ▸ | TEC | P42680 | 1/20 | 0.41 |
| ▸ | BLK | P51451 | 1/20 | 0.41 |
| ▸ | BMX | P51813 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.41 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6638074 | 0.82 | BTK (0.46) | BTKLCKLYNEGFRITK | |
| SCHEMBL6641651 | 0.81 | BTK (0.50) | BTKLCKLYNEGFRITK | |
| SCHEMBL6430757 | 0.81 | BTK (0.70) | BTKLCKLYNEGFRITK | |
| SCHEMBL5803835 | 0.80 | BTK (0.50) | BTKLCKLYNEGFRSRC | |
| SCHEMBL6692147 | 0.79 | BTK (0.58) | BTKLCKEGFRITKNUDT14 | |
| SCHEMBL6690528 | 0.79 | BTK (0.49) | BTKLCKLYNEGFRSRC | |
| SCHEMBL6689789 | 0.79 | BTK (0.49) | BTKLCKLYNEGFRSRC | |
| SCHEMBL6693408 | 0.79 | BTK (0.56) | BTKLCKEGFRITK | |
| SCHEMBL6688163 | 0.78 | BTK (0.58) | BTKLCKEGFRITKSRC | |
| SCHEMBL5818332 | 0.78 | BTK (0.48) | BTKLCKLYNEGFRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1385524-A4 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO KG (DE) | 2006-02-01 | — | — | EP | disclosed |
| EP-1385524-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | Abbott GmbH & Co. KG (DE) | 2004-02-04 | — | — | EP | disclosed |
| WO-2002080926-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO. KG (DE) | 2002-10-17 | — | — | WO | disclosed |