Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 5/20 | 0.46 |
| ▸ | RET | P07949 | 3/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.46 |
| ▸ | LTK | P29376 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.46 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.46 |
| ▸ | CDK7 | P50613 | 2/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.46 |
| ▸ | MST1R | Q04912 | 2/20 | 0.46 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.46 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5822217 | 1.00 | NTRK1 (0.46) | NTRK1RETPRKD3ABL1PDGFRB | |
| SCHEMBL7783118 | 0.78 | NTRK1 (0.55) | NTRK1RETPRKD3ABL1PDGFRB | |
| SCHEMBL14448859 | 0.76 | NTRK1 (0.55) | NTRK1RETPRKD3ABL1PDGFRB | |
| SCHEMBL5478687 | 0.76 | NTRK1 (0.55) | NTRK1RETPRKD3ABL1PDGFRB | |
| SCHEMBL5478682 | 0.76 | NTRK1 (0.55) | NTRK1RETPRKD3ABL1PDGFRB | |
| SCHEMBL27175573 | 0.73 | ACHE (0.55) | NTRK1RETPRKD3ABL1PDGFRB | |
| SCHEMBL7694409 | 0.73 | NTRK1 (0.52) | NTRK1RETPRKD3ABL1PDGFRB | |
| SCHEMBL5468602 | 0.72 | MAPT (0.47) | NTRK1RETPRKD3ABL1PDGFRB | |
| SCHEMBL14448846 | 0.72 | MAPT (0.47) | NTRK1RETPRKD3ABL1PDGFRB | |
| SCHEMBL5468598 | 0.72 | MAPT (0.47) | NTRK1RETPRKD3ABL1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006105796-A1 | NOVEL INDOLINONE DERIVATIVES | LEO PHARMA A/S (DK) | 2006-10-12 | — | — | WO | disclosed |