Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 4/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.41 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.39 |
| ▸ | GLS | O94925 | 1/20 | 0.39 |
| ▸ | TERT | O14746 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1807288 | 0.86 | P2RX7 (0.49) | P2RX7KCNQ3KCNQ2PTGER4GBA1 | |
| SCHEMBL13813697 | 0.86 | P2RX7 (0.55) | P2RX7EPHX2KCNQ3KCNQ2PTGER4 | |
| SCHEMBL1803661 | 0.86 | P2RX7 (0.55) | P2RX7EPHX2KCNQ3KCNQ2PTGER4 | |
| SCHEMBL1803060 | 0.85 | P2RX7 (0.44) | P2RX7KCNQ3KCNQ2PTGER4GBA1 | |
| SCHEMBL1803748 | 0.81 | P2RX7 (0.49) | P2RX7EPHX2KCNQ3KCNQ2PTGER4 | |
| SCHEMBL1804098 | 0.81 | P2RX7 (0.54) | P2RX7KCNQ3KCNQ2 | |
| SCHEMBL3837025 | 0.81 | P2RX7 (0.54) | P2RX7KCNQ3KCNQ2 | |
| SCHEMBL3840967 | 0.81 | KCNQ3 (0.46) | P2RX7KCNQ3KCNQ2PTGER4GBA1 | |
| SCHEMBL13972650 | 0.80 | P2RX7 (0.43) | P2RX7PTGER4GBA1MCHR1 | |
| SCHEMBL13972676 | 0.78 | P2RX7 (0.42) | P2RX7PTGER4GBA1MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633717-A1 | NEW P2X7 RECEPTOR ANTAGONISTS AND THEIR USE | AstraZeneca AB (SE) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004106305-A1 | NEW P2X7 RECEPTOR ANTAGONISTS AND THEIR USE | ASTRAZENECA AB (SE) | 2004-12-09 | — | — | WO | disclosed |