Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 12/20 | 0.51 |
| ▸ | LCK | P06239 | 10/20 | 0.51 |
| ▸ | TEK | Q02763 | 8/20 | 0.51 |
| ▸ | KDR | P35968 | 6/20 | 0.51 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.51 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 5/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.48 |
| ▸ | ABL1 | P00519 | 3/20 | 0.48 |
| ▸ | HCK | P08631 | 3/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.48 |
| ▸ | MTOR | P42345 | 3/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.48 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.48 |
| ▸ | PRKDC | P78527 | 3/20 | 0.48 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5822928 | 0.88 | SRC (0.65) | SRCLCKTEKKDRLIMK1 | |
| SCHEMBL6637623 | 0.88 | SRC (0.46) | SRCLCKTEKKDRLIMK1 | |
| SCHEMBL5823668 | 0.87 | SRC (0.57) | SRCLCKTEKKDRLIMK1 | |
| SCHEMBL6220508 | 0.85 | SRC (0.51) | SRCLCKKDREGFRPIK3CD | |
| SCHEMBL5821936 | 0.81 | GRIN2B (0.50) | SMN1; SMN2CYP2C19NPC1RAB9A | |
| SCHEMBL6274140 | 0.77 | SRC (0.46) | SRCLCKTEKKDRLIMK1 | |
| SCHEMBL5813953 | 0.77 | SRC (0.56) | SRCLCKTEKKDRLIMK1 | |
| SCHEMBL5823664 | 0.77 | LCK (0.71) | SRCLCKTEKKDRLIMK1 | |
| SCHEMBL5819470 | 0.76 | SRC (0.56) | SRCLCKTEKKDRLIMK1 | |
| SCHEMBL5801721 | 0.76 | LCK (0.66) | SRCLCKTEKKDRLIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1385524-A4 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO KG (DE) | 2006-02-01 | — | — | EP | disclosed |
| EP-1385524-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | Abbott GmbH & Co. KG (DE) | 2004-02-04 | — | — | EP | disclosed |
| WO-2002080926-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO. KG (DE) | 2002-10-17 | — | — | WO | disclosed |