Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 9/20 | 0.51 |
| ▸ | ABL1 | P00519 | 8/20 | 0.51 |
| ▸ | KDR | P35968 | 6/20 | 0.51 |
| ▸ | EGFR | P00533 | 6/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.51 |
| ▸ | HCK | P08631 | 5/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.51 |
| ▸ | MTOR | P42345 | 5/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.51 |
| ▸ | EPHB4 | P54760 | 5/20 | 0.51 |
| ▸ | PRKDC | P78527 | 5/20 | 0.51 |
| ▸ | PI4KB | Q9UBF8 | 5/20 | 0.51 |
| ▸ | CFTR | P13569 | 3/20 | 0.48 |
| ▸ | ITK | Q08881 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.43 |
| ▸ | LCK | P06239 | 2/20 | 0.42 |
| ▸ | ABL2 | P42684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4823038 | 0.87 | KDR (0.70) | SRCABL1KDREGFRPIK3CD | |
| SCHEMBL5822010 | 0.87 | SRC (0.48) | SRCABL1KDREGFRPIK3CD | |
| SCHEMBL5822930 | 0.85 | SRC (0.51) | SRCABL1KDREGFRPIK3CD | |
| SCHEMBL2365351 | 0.81 | BTK (0.53) | SRCABL1KDREGFRPIK3CD | |
| SCHEMBL5823904 | 0.81 | CFTR (0.45) | SRCABL1KDREGFRPIK3CD | |
| SCHEMBL5812726 | 0.81 | SRC (0.61) | SRCABL1KDREGFRPIK3CD | |
| SCHEMBL5813953 | 0.81 | SRC (0.56) | SRCABL1KDREGFRPIK3CD | |
| SCHEMBL5823668 | 0.80 | SRC (0.57) | SRCABL1KDREGFRPIK3CD | |
| SCHEMBL5820596 | 0.80 | SRC (0.44) | SRCABL1KDREGFRPIK3CD | |
| SCHEMBL5819470 | 0.79 | SRC (0.56) | SRCABL1KDREGFRPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379528-A4 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH (DE) | 2005-12-07 | — | — | EP | disclosed |
| EP-1379528-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GmbH (DE) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002076986-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO. KG (DE) | 2002-10-03 | — | — | WO | disclosed |