Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17B | O94768 | 1/20 | 0.43 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 5/20 | 0.37 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 2/20 | 0.32 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.32 |
| ▸ | CKS1B | P61024 | 1/20 | 0.31 |
| ▸ | SKP1 | P63208 | 1/20 | 0.31 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5306339 | 0.89 | STK17B (0.49) | STK17BSTK17AAAK1ATRMAPKAPK2 | |
| SCHEMBL3176616 | 0.87 | STK17B (0.42) | STK17BSTK17AAAK1ATRMAPKAPK2 | |
| SCHEMBL8244837 | 0.87 | STK17B (0.42) | STK17BSTK17AAAK1ATRMAPKAPK2 | |
| SCHEMBL5792631 | 0.86 | STK17B (0.42) | STK17BSTK17AAAK1TRPA1 | |
| SCHEMBL5791907 | 0.83 | CTSS (0.34) | AAK1NUDT1MAPKAPK2SYKAKT1 | |
| SCHEMBL8125809 | 0.77 | ATR (0.42) | STK17BSTK17AAAK1ATRMAPKAPK2 | |
| SCHEMBL8243223 | 0.76 | STK17B (0.41) | STK17BSTK17AAAK1ATRMAPKAPK2 | |
| SCHEMBL5304940 | 0.76 | STK17B (0.41) | STK17BSTK17AAAK1ATRMAPKAPK2 | |
| SCHEMBL5306326 | 0.75 | STK17B (0.47) | STK17BSTK17AAAK1ATRTRPA1 | |
| SCHEMBL5303425 | 0.75 | STK17B (0.38) | STK17BSTK17AAAK1ATRMAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006027211-A1 | 2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-03-16 | — | — | WO | disclosed |