SCHEMBL5823973

SCHEMBL5823973

COC(=O)c1ccc(C#CCN(C(=O)c2cc3ccccc3s2)c2ccccc2)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 5/20 0.42
HDAC3 O15379 4/20 0.42
HDAC2 Q92769 4/20 0.42
BCL2L1 Q07817 1/20 0.41
OPRM1 P35372 4/20 0.39
NPY2R P49146 3/20 0.39
HDAC4 P56524 1/20 0.38
HDAC7 Q8WUI4 1/20 0.38
HDAC10 Q969S8 1/20 0.38
HDAC11 Q96DB2 1/20 0.38
HDAC8 Q9BY41 1/20 0.38
HDAC6 Q9UBN7 1/20 0.38
HDAC9 Q9UKV0 1/20 0.38
HDAC5 Q9UQL6 1/20 0.38
TAS1R3 Q7RTX0 2/20 0.37
TAS1R1 Q7RTX1 2/20 0.37
CLK1 P49759 1/20 0.37
DYRK1A Q13627 1/20 0.37
TSHR P16473 2/20 0.37
KDM4E B2RXH2 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4809196 0.79 RAB9A (0.51) HDAC1HDAC3HDAC2BCL2L1OPRM1
SCHEMBL4819143 0.76 HDAC1 (0.53) HDAC1HDAC3HDAC2OPRM1HDAC4
SCHEMBL29525076 0.76 MAPT (0.43) TSHRKDM4EALDH1A1CYP1A2CYP2C9
SCHEMBL4252197 0.74 HDAC2 (0.44) HDAC1HDAC3HDAC2BCL2L1OPRM1
SCHEMBL4817432 0.70 HDAC1 (0.59) HDAC1HDAC3HDAC2OPRM1HDAC4
SCHEMBL700108 0.69 BCL2L1 (0.68) HDAC1HDAC3HDAC2BCL2L1HDAC4
SCHEMBL29445494 0.69 BCL2L1 (0.68) HDAC1HDAC3HDAC2BCL2L1HDAC4
SCHEMBL21446740 0.68 HDAC1 (0.58) HDAC1HDAC3HDAC2BCL2L1HDAC4
SCHEMBL23128710 0.67 PTPN11 (0.56) TSHRKDM4EALDH1A1CYP1A2CYP2C9
SCHEMBL447695 0.67 RAB9A (0.57) HDAC1HDAC3HDAC2OPRM1HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006042035-A2 METHOD OF MONITORING ANTI-TUMOR ACTIVITY OF AN HDAC INHIBITOR PHARMACYCLICS, INC. (US) 2006-04-20 WO disclosed