Sugi Predict

Sugi Predict / Compounds / SCHEMBL5825065

SCHEMBL5825065

SCHEMBL5825065

CCN(CCNC(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cc1Cl)c1cccc(C)c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDR P35968 18/20 0.58
▸ PDGFRA P16234 10/20 0.57
▸ FLT1 P17948 4/20 0.57
▸ FLT4 P35916 4/20 0.57
▸ KIT P10721 4/20 0.57
▸ MET P08581 3/20 0.57
▸ EPHB2 P29323 2/20 0.57
▸ RIPK2 O43353 2/20 0.57
▸ STK10 O94804 2/20 0.57
▸ ABL1 P00519 2/20 0.57
▸ RET P07949 2/20 0.57
▸ PDGFRB P09619 2/20 0.57
▸ BCR P11274 2/20 0.57
▸ FGFR1 P11362 2/20 0.57
▸ SLC6A3 Q01959 2/20 0.57
▸ DDR1 Q08345 2/20 0.57
▸ MAP4K2 Q12851 2/20 0.57
▸ PTK6 Q13882 2/20 0.57
▸ DDR2 Q16832 2/20 0.57
▸ AURKB Q96GD4 2/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5825326 0.93 KDR (0.54) KDRPDGFRAFLT1FLT4KIT
SCHEMBL5825829 0.89 KDR (0.71) KDRPDGFRAFLT1FLT4KIT
SCHEMBL5825434 0.89 PDGFRA (0.67) KDRPDGFRA
SCHEMBL5825041 0.89 KDR (0.55) KDRPDGFRAKITMETAURKB
SCHEMBL5824466 0.87 PDGFRA (0.48) KDRPDGFRAKITMETSRC
SCHEMBL5825547 0.86 KDR (0.65) KDRPDGFRAFLT1FLT4KIT
SCHEMBL5825425 0.86 PDGFRA (0.48) KDRPDGFRAKITMETSRC
SCHEMBL5205528 0.83 KDR (0.75) KDRPDGFRAFLT1FLT4KIT
SCHEMBL5824679 0.82 KDR (0.60) KDRPDGFRAFLT1FLT4KIT
SCHEMBL5206215 0.79 KDR (0.65) KDRPDGFRAFLT1FLT4KIT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7135466-B2 Quinoline and quinazoline derivatives and drugs containing the same KIRIN BEER KABUSHIKI KAISHA (JP) 2006-11-14 — — US claimed
US-7135466-B2 Quinoline and quinazoline derivatives and drugs containing the same KIRIN BEER KABUSHIKI KAISHA (JP) 2006-11-14 — — US disclosed
US-20060211717-A1 Quinoline and quinazoline derivatives and drugs containing the same KIRIN BEER KABUSHIKI KAISHA (JP) 2006-09-21 — — US disclosed
US-20040132727-A1 Quinoline and quinazoline derivatives and drugs containing the same KIRIN HOLDINGS KABUSHIKI KAISHA (JP) 2004-07-08 — — US disclosed
EP-1243582-A1 QUINOLINE AND QUINAZOLINE DERIVATIVES AND DRUGS CONTAINING THE SAME KIRIN BEER KABUSHIKI KAISHA (JP) 2002-09-25 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060211717-A1 Quinoline and quinazoline derivatives and drugs containing the same PDGFRA, PDGFRB, PDGFA KDR 4/4885PDGFRA 1/4885FLT1 5/4885
US-20040132727-A1 Quinoline and quinazoline derivatives and drugs containing the same PDGFRA, PDGFRB, PDGFA KDR 5/4885PDGFRA 1/4885FLT1 6/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.