Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 11/20 | 0.53 |
| ▸ | KDR | P35968 | 10/20 | 0.53 |
| ▸ | KIT | P10721 | 1/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.50 |
| ▸ | AXL | P30530 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | LYN | P07948 | 1/20 | 0.48 |
| ▸ | MET | P08581 | 1/20 | 0.48 |
| ▸ | TEK | Q02763 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5826134 | 0.88 | PDGFRA (0.66) | PDGFRAKDRKITFGFR2AXL | |
| SCHEMBL5825195 | 0.88 | PDGFRA (0.62) | PDGFRAKDRKITFGFR2PDGFRB | |
| SCHEMBL1894474 | 0.86 | AXL (0.56) | PDGFRAKDRKITFGFR2AXL | |
| SCHEMBL5825964 | 0.84 | SRC (0.47) | PDGFRAKDRFGFR2METPDGFRB | |
| SCHEMBL5826132 | 0.84 | SRC (0.48) | PDGFRAKDRKITAURKAABL1 | |
| SCHEMBL5825677 | 0.83 | PDGFRA (0.60) | PDGFRAKDRKITFGFR2AXL | |
| SCHEMBL5825967 | 0.83 | FGFR2 (0.68) | PDGFRAKDRKITFGFR2AXL | |
| SCHEMBL5825889 | 0.82 | PDGFRA (0.58) | PDGFRAKDRKITFGFR2AXL | |
| SCHEMBL5826095 | 0.81 | FGFR2 (0.74) | PDGFRAKDRKITFGFR2MET | |
| SCHEMBL5825989 | 0.81 | PDGFRA (0.61) | PDGFRAKDRKITFGFR2AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7135466-B2 | Quinoline and quinazoline derivatives and drugs containing the same | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-14 | — | — | US | claimed |