Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 3/20 | 0.56 |
| ▸ | MET | P08581 | 2/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 11/20 | 0.53 |
| ▸ | KDR | P35968 | 7/20 | 0.53 |
| ▸ | KIT | P10721 | 2/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.50 |
| ▸ | CSF1R | P07333 | 1/20 | 0.50 |
| ▸ | FLT4 | P35916 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5826134 | 0.89 | PDGFRA (0.66) | AXLPDGFRAKDRKITFGFR2 | |
| SCHEMBL5825299 | 0.86 | PDGFRA (0.53) | AXLMETPDGFRAKDRKIT | |
| SCHEMBL5825967 | 0.84 | FGFR2 (0.68) | AXLPDGFRAKDRKITFGFR2 | |
| SCHEMBL1893941 | 0.82 | PDGFRA (0.79) | AXLMETPDGFRAKDRKIT | |
| SCHEMBL5825195 | 0.82 | PDGFRA (0.62) | PDGFRAKDRKITFGFR2PDGFRB | |
| SCHEMBL2174773 | 0.81 | MET (0.61) | AXLMETPDGFRAKDRKIT | |
| SCHEMBL5825989 | 0.81 | PDGFRA (0.61) | AXLMETPDGFRAKDRKIT | |
| SCHEMBL14967576 | 0.81 | MET (0.60) | AXLMETPDGFRAKDRKIT | |
| SCHEMBL1893637 | 0.80 | PDGFRA (0.80) | AXLMETPDGFRAKDRKIT | |
| SCHEMBL5825677 | 0.80 | PDGFRA (0.60) | AXLMETPDGFRAKDRKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8372981-B2 | Nitrogen-containing aromatic derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-02-12 | — | — | US | disclosed |
| US-20110118470-A1 | NITROGEN-CONTAINING AROMATIC DERIVATIVES | FUNAHASHI YASUHIRO | 2011-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118470-A1 | NITROGEN-CONTAINING AROMATIC DERIVATIVES | GNG2, GCG, FRG1 | AXL 3184/4885MET 1619/4885PDGFRA 3135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.