Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.64 |
| ▸ | PDGFRA | P16234 | 12/20 | 0.64 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.52 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.52 |
| ▸ | KIT | P10721 | 2/20 | 0.52 |
| ▸ | AXL | P30530 | 1/20 | 0.52 |
| ▸ | CSF1R | P07333 | 2/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | MET | P08581 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 1/20 | 0.51 |
| ▸ | FLT1 | P17948 | 1/20 | 0.51 |
| ▸ | FLT4 | P35916 | 1/20 | 0.51 |
| ▸ | TEK | Q02763 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5825958 | 0.93 | PDGFRA (0.62) | KDRPDGFRAAURKBFLT3PDGFRB | |
| SCHEMBL5825951 | 0.91 | PDGFRA (0.63) | KDRPDGFRAAURKBFLT3PDGFRB | |
| SCHEMBL5826016 | 0.91 | PDGFRA (0.59) | KDRPDGFRAAURKBFLT3PDGFRB | |
| SCHEMBL371517 | 0.91 | PDGFRA (0.62) | KDRPDGFRAPDGFRBFGFR2KIT | |
| SCHEMBL5825831 | 0.91 | KDR (0.60) | KDRPDGFRAFGFR2KITAXL | |
| SCHEMBL5825647 | 0.90 | KDR (0.64) | KDRPDGFRAAURKBFLT3FGFR2 | |
| SCHEMBL5826044 | 0.90 | PDGFRA (0.56) | KDRPDGFRAAURKBFLT3PDGFRB | |
| SCHEMBL5825982 | 0.88 | FGFR2 (0.68) | KDRPDGFRAAURKBFLT3PDGFRB | |
| SCHEMBL5826045 | 0.87 | FGFR2 (0.56) | KDRPDGFRAAURKBFLT3PDGFRB | |
| SCHEMBL5825683 | 0.87 | KDR (0.61) | KDRPDGFRAAURKBPDGFRBFGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7135466-B2 | Quinoline and quinazoline derivatives and drugs containing the same | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-14 | — | — | US | claimed |