Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 8/20 | 0.56 |
| ▸ | KDR | P35968 | 5/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.54 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.53 |
| ▸ | KIT | P10721 | 2/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.52 |
| ▸ | MET | P08581 | 4/20 | 0.52 |
| ▸ | AXL | P30530 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5825958 | 0.93 | PDGFRA (0.62) | PDGFRAKDRPDGFRBFGFR2KIT | |
| SCHEMBL371517 | 0.93 | PDGFRA (0.62) | PDGFRAKDRPDGFRBFGFR2KIT | |
| SCHEMBL5825951 | 0.91 | PDGFRA (0.63) | PDGFRAKDRPDGFRBFGFR2KIT | |
| SCHEMBL5826016 | 0.91 | PDGFRA (0.59) | PDGFRAKDRPDGFRBFGFR2KIT | |
| SCHEMBL5825647 | 0.90 | KDR (0.64) | PDGFRAKDRFGFR2KITFLT3 | |
| SCHEMBL5826010 | 0.90 | KDR (0.64) | PDGFRAKDRPDGFRBFGFR2KIT | |
| SCHEMBL5826045 | 0.89 | FGFR2 (0.56) | PDGFRAKDRPDGFRBFGFR2KIT | |
| SCHEMBL5825982 | 0.88 | FGFR2 (0.68) | PDGFRAKDRPDGFRBFGFR2KIT | |
| SCHEMBL5825336 | 0.88 | PDGFRA (0.59) | PDGFRAKDRFGFR2KITMET | |
| SCHEMBL5825584 | 0.87 | PDGFRA (0.59) | PDGFRAKDRFGFR2KITAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7135466-B2 | Quinoline and quinazoline derivatives and drugs containing the same | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-14 | — | — | US | claimed |