Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.53 |
| ▸ | MET | P08581 | 8/20 | 0.50 |
| ▸ | AURKA | O14965 | 2/20 | 0.50 |
| ▸ | TEK | Q02763 | 2/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.50 |
| ▸ | AXL | P30530 | 1/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.49 |
| ▸ | KIT | P10721 | 2/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL371654 | 0.88 | PDGFRA (0.59) | KDRMETAURKBAXLPDGFRA | |
| SCHEMBL5826100 | 0.85 | MET (0.46) | KDRMETAURKATEKAURKB | |
| SCHEMBL371655 | 0.85 | PDGFRA (0.59) | KDRMETAURKBAXLPDGFRA | |
| SCHEMBL5825959 | 0.84 | SRC (0.46) | KDRMETAURKATEKAURKB | |
| SCHEMBL5826045 | 0.84 | FGFR2 (0.56) | KDRMETAURKBPDGFRAFGFR2 | |
| SCHEMBL5825624 | 0.84 | PDGFRA (0.58) | KDRMETAXLPDGFRAFGFR2 | |
| SCHEMBL15519428 | 0.82 | MET (0.53) | KDRMETAXL | |
| SCHEMBL371517 | 0.82 | PDGFRA (0.62) | KDRMETAXLPDGFRAFGFR2 | |
| SCHEMBL5826068 | 0.81 | PDGFRA (0.58) | KDRMETAURKBAXLPDGFRA | |
| SCHEMBL5825290 | 0.80 | PDGFRA (0.62) | KDRMETAXLPDGFRAKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7135466-B2 | Quinoline and quinazoline derivatives and drugs containing the same | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-14 | — | — | US | claimed |