Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 13/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 10/20 | 0.55 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5829211 | 0.88 | WEE1 (0.56) | WEE1CHEK1CDK1 | |
| SCHEMBL5829407 | 0.87 | WEE1 (0.71) | WEE1CHEK1CDK1 | |
| SCHEMBL5827723 | 0.86 | WEE1 (0.54) | WEE1CHEK1CDK1 | |
| SCHEMBL5827727 | 0.83 | WEE1 (0.57) | WEE1CHEK1CDK1 | |
| SCHEMBL5829083 | 0.82 | WEE1 (0.58) | WEE1CHEK1CDK1 | |
| SCHEMBL5829171 | 0.81 | WEE1 (0.56) | WEE1CHEK1CDK1KDM4E | |
| SCHEMBL5829464 | 0.79 | WEE1 (0.54) | WEE1CHEK1CDK1MEN1KMT2A | |
| SCHEMBL6230406 | 0.78 | WEE1 (0.70) | WEE1CHEK1CDK1 | |
| SCHEMBL5828251 | 0.74 | WEE1 (0.74) | WEE1CHEK1CDK1 | |
| SCHEMBL6209974 | 0.73 | WEE1 (0.64) | WEE1CHEK1CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7094798-B1 | Inhibitors of checkpoint kinases (Wee1 and Chk1) | PFIZER INC (US) | 2006-08-22 | — | — | US | disclosed |