Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 3/20 | 0.52 |
| ▸ | EGFR | P00533 | 11/20 | 0.52 |
| ▸ | KDR | P35968 | 12/20 | 0.52 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.52 |
| ▸ | CSK | P41240 | 1/20 | 0.52 |
| ▸ | TEK | Q02763 | 1/20 | 0.52 |
| ▸ | RET | P07949 | 2/20 | 0.51 |
| ▸ | KIF5B | P33176 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | FLT1 | P17948 | 1/20 | 0.49 |
| ▸ | FLT4 | P35916 | 1/20 | 0.49 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5828191 | 1.00 | SRC (0.52) | SRCEGFRKDREPHB4CSK | |
| SCHEMBL5496207 | 0.85 | SRC (0.58) | SRCEGFRKDREPHB4CSK | |
| SCHEMBL4687659 | 0.85 | SRC (0.58) | SRCEGFRKDREPHB4CSK | |
| SCHEMBL5496725 | 0.78 | KDR (0.62) | EGFRKDRRETKIF5BAURKA | |
| SCHEMBL6980090 | 0.78 | EGFR (0.60) | SRCEGFRKDRCSKTEK | |
| SCHEMBL5828858 | 0.78 | KDR (0.48) | SRCEGFRKDREPHB4CSK | |
| SCHEMBL6984923 | 0.78 | EGFR (0.52) | SRCEGFRKDREPHB4CSK | |
| SCHEMBL5828856 | 0.78 | KDR (0.48) | SRCEGFRKDREPHB4CSK | |
| SCHEMBL4422030 | 0.76 | EGFR (0.57) | EGFRKDRAURKA | |
| SCHEMBL4691264 | 0.76 | EGFR (0.61) | SRCEGFRKDRCSKTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7001904-B1 | Guanidine derivatives quinazoline and quinoline for use in the treatment of autoimmune diseases | ASTRAZENECA AB (SE) | 2006-02-21 | — | — | US | disclosed |