Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.48 |
| ▸ | FLT1 | P17948 | 13/20 | 0.48 |
| ▸ | FLT4 | P35916 | 13/20 | 0.48 |
| ▸ | SRC | P12931 | 2/20 | 0.47 |
| ▸ | CSK | P41240 | 1/20 | 0.47 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.47 |
| ▸ | TEK | Q02763 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 3/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5828858 | 1.00 | KDR (0.48) | KDRFLT1FLT4SRCCSK | |
| SCHEMBL6984923 | 0.86 | EGFR (0.52) | KDRFLT1FLT4SRCCSK | |
| SCHEMBL5827935 | 0.80 | EGFR (0.50) | KDRFLT1FLT4EGFRRET | |
| SCHEMBL5827933 | 0.80 | EGFR (0.50) | KDRFLT1FLT4EGFRRET | |
| SCHEMBL5828263 | 0.80 | PDGFRB (0.52) | KDRFLT1FLT4EGFRRET | |
| SCHEMBL5828257 | 0.80 | PDGFRB (0.52) | KDRFLT1FLT4EGFRRET | |
| SCHEMBL5496207 | 0.79 | SRC (0.58) | KDRFLT1FLT4SRCCSK | |
| SCHEMBL4687659 | 0.79 | SRC (0.58) | KDRFLT1FLT4SRCCSK | |
| SCHEMBL5828192 | 0.78 | SRC (0.52) | KDRFLT1FLT4SRCCSK | |
| SCHEMBL5828191 | 0.78 | SRC (0.52) | KDRFLT1FLT4SRCCSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7001904-B1 | Guanidine derivatives quinazoline and quinoline for use in the treatment of autoimmune diseases | ASTRAZENECA AB (SE) | 2006-02-21 | — | — | US | claimed |
| US-7001904-B1 | Guanidine derivatives quinazoline and quinoline for use in the treatment of autoimmune diseases | ASTRAZENECA AB (SE) | 2006-02-21 | — | — | US | disclosed |