Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.53 |
| ▸ | KDR | P35968 | 8/20 | 0.49 |
| ▸ | SRC | P12931 | 2/20 | 0.49 |
| ▸ | CSK | P41240 | 1/20 | 0.49 |
| ▸ | TEK | Q02763 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.48 |
| ▸ | FLT1 | P17948 | 4/20 | 0.48 |
| ▸ | FLT4 | P35916 | 4/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | KIF5B | P33176 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5828489 | 1.00 | EGFR (0.53) | EGFRKDRSRCCSKTEK | |
| SCHEMBL5829124 | 0.88 | KDR (0.51) | EGFRKDRSRCCSKTEK | |
| SCHEMBL5829126 | 0.88 | KDR (0.51) | EGFRKDRSRCCSKTEK | |
| SCHEMBL5827935 | 0.85 | EGFR (0.50) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL5827933 | 0.85 | EGFR (0.50) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL5828894 | 0.85 | EGFR (0.52) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL5828900 | 0.85 | EGFR (0.52) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL6980090 | 0.84 | EGFR (0.60) | EGFRKDRSRCCSKTEK | |
| SCHEMBL5827926 | 0.84 | RAF1 (0.47) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL5827928 | 0.84 | RAF1 (0.47) | EGFRKDRFGFR1FLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7001904-B1 | Guanidine derivatives quinazoline and quinoline for use in the treatment of autoimmune diseases | ASTRAZENECA AB (SE) | 2006-02-21 | — | — | US | claimed |
| US-7001904-B1 | Guanidine derivatives quinazoline and quinoline for use in the treatment of autoimmune diseases | ASTRAZENECA AB (SE) | 2006-02-21 | — | — | US | disclosed |
| EP-1296973-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | AstraZeneca AB (SE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2002000644-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2002-01-03 | — | — | WO | disclosed |