Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.51 |
| ▸ | RET | P07949 | 2/20 | 0.51 |
| ▸ | KIF5B | P33176 | 2/20 | 0.51 |
| ▸ | EGFR | P00533 | 18/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.49 |
| ▸ | FLT1 | P17948 | 6/20 | 0.49 |
| ▸ | FLT4 | P35916 | 6/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.48 |
| ▸ | TEK | Q02763 | 2/20 | 0.48 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | CIT | O14578 | 1/20 | 0.48 |
| ▸ | GAK | O14976 | 1/20 | 0.48 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | STK10 | O94804 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5829126 | 1.00 | KDR (0.51) | KDRRETKIF5BEGFRFGFR1 | |
| SCHEMBL5828900 | 0.89 | EGFR (0.52) | KDRRETKIF5BEGFRFGFR1 | |
| SCHEMBL5827933 | 0.89 | EGFR (0.50) | KDRRETKIF5BEGFRFGFR1 | |
| SCHEMBL5827935 | 0.89 | EGFR (0.50) | KDRRETKIF5BEGFRFGFR1 | |
| SCHEMBL5828894 | 0.89 | EGFR (0.52) | KDRRETKIF5BEGFRFGFR1 | |
| SCHEMBL5828489 | 0.88 | EGFR (0.53) | KDRRETKIF5BEGFRFGFR1 | |
| SCHEMBL5828485 | 0.88 | EGFR (0.53) | KDRRETKIF5BEGFRFGFR1 | |
| SCHEMBL5827926 | 0.88 | RAF1 (0.47) | KDRRETKIF5BEGFRFGFR1 | |
| SCHEMBL5827928 | 0.88 | RAF1 (0.47) | KDRRETKIF5BEGFRFGFR1 | |
| SCHEMBL5828194 | 0.86 | RAF1 (0.48) | KDRRETKIF5BEGFRFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7001904-B1 | Guanidine derivatives quinazoline and quinoline for use in the treatment of autoimmune diseases | ASTRAZENECA AB (SE) | 2006-02-21 | — | — | US | disclosed |