Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 17/20 | 0.74 |
| ▸ | CHEK1 | O14757 | 15/20 | 0.74 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.57 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | PAK4 | O96013 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | FYN | P06241 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | PRKACA | P17612 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | LTK | P29376 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.51 |
| ▸ | SYK | P43405 | 1/20 | 0.51 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.51 |
| ▸ | GSK3A | P49840 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5829093 | 0.86 | WEE1 (0.78) | WEE1CHEK1ROCK2PDGFRBDAPK3 | |
| SCHEMBL5829173 | 0.85 | WEE1 (0.77) | WEE1CHEK1ROCK2PDGFRBDAPK3 | |
| SCHEMBL5828158 | 0.85 | WEE1 (0.77) | WEE1CHEK1ROCK2PDGFRBDAPK3 | |
| SCHEMBL5827976 | 0.85 | WEE1 (0.77) | WEE1CHEK1ROCK2PDGFRBDAPK3 | |
| SCHEMBL5827986 | 0.85 | WEE1 (0.77) | WEE1CHEK1ROCK2PDGFRBPRKCQ | |
| SCHEMBL5828256 | 0.84 | WEE1 (1.00) | WEE1CHEK1DAPK3JAK2PAK4 | |
| SCHEMBL5829332 | 0.81 | WEE1 (0.73) | WEE1CHEK1ROCK2PDGFRB | |
| SCHEMBL5828682 | 0.80 | WEE1 (0.83) | WEE1CHEK1ROCK2PDGFRBDAPK3 | |
| SCHEMBL5828726 | 0.80 | WEE1 (0.83) | WEE1CHEK1ROCK2PDGFRBDAPK3 | |
| SCHEMBL5828632 | 0.79 | CHEK1 (0.76) | WEE1CHEK1ROCK2PDGFRBDAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7094798-B1 | Inhibitors of checkpoint kinases (Wee1 and Chk1) | PFIZER INC (US) | 2006-08-22 | — | — | US | disclosed |