Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 9/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 3/20 | 0.52 |
| ▸ | MAOB | P27338 | 3/20 | 0.52 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5828701 | 1.00 | APP (0.74) | APPALDH1A1HPGDTP53SMN1; SMN2 | |
| SCHEMBL1804423 | 0.91 | APP (0.83) | APPALDH1A1HPGDTP53SMN1; SMN2 | |
| SCHEMBL1804421 | 0.91 | APP (0.83) | APPALDH1A1HPGDTP53SMN1; SMN2 | |
| SCHEMBL9727779 | 0.85 | APP (0.75) | APPALDH1A1HPGDTP53SMN1; SMN2 | |
| SCHEMBL1806011 | 0.85 | APP (1.00) | APPALDH1A1HPGDTP53SMN1; SMN2 | |
| SCHEMBL1806013 | 0.85 | APP (1.00) | APPALDH1A1HPGDTP53SMN1; SMN2 | |
| SCHEMBL1512213 | 0.85 | APP (0.66) | APPALDH1A1HPGDTP53SMN1; SMN2 | |
| SCHEMBL1512215 | 0.85 | APP (0.66) | APPALDH1A1HPGDTP53SMN1; SMN2 | |
| SCHEMBL1808247 | 0.83 | APP (1.00) | APPALDH1A1HPGDTP53SMN1; SMN2 | |
| SCHEMBL1804704 | 0.83 | APP (1.00) | APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7094798-B1 | Inhibitors of checkpoint kinases (Wee1 and Chk1) | PFIZER INC (US) | 2006-08-22 | — | — | US | disclosed |