Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 12/20 | 0.75 |
| ▸ | MAOA | P21397 | 3/20 | 0.70 |
| ▸ | MAOB | P27338 | 3/20 | 0.70 |
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | AHR | P35869 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1810321 | 0.93 | APP (0.69) | APPMAOAMAOBMAPTKDM4E | |
| SCHEMBL1810320 | 0.93 | APP (0.69) | APPMAOAMAOBMAPTKDM4E | |
| SCHEMBL1804421 | 0.91 | APP (0.83) | APPMAOAMAOBMAPTKDM4E | |
| SCHEMBL1804423 | 0.91 | APP (0.83) | APPMAOAMAOBMAPTKDM4E | |
| SCHEMBL1806011 | 0.86 | APP (1.00) | APPMAOAMAOBMAPTKDM4E | |
| SCHEMBL1806013 | 0.86 | APP (1.00) | APPMAOAMAOBMAPTKDM4E | |
| SCHEMBL5828701 | 0.85 | APP (0.74) | APPMAOAMAOBMAPTKDM4E | |
| SCHEMBL5828704 | 0.85 | APP (0.74) | APPMAOAMAOBMAPTKDM4E | |
| SCHEMBL1808248 | 0.83 | APP (1.00) | APPMAOAMAOBMAPTKDM4E | |
| SCHEMBL1804707 | 0.83 | APP (1.00) | APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091533-A | Treating allergies, cardiovascular disorders, inflammation | MERCK FROSST CANADA, INC. (CA) | 1992-02-25 | — | — | US | disclosed |
| EP-0447189-A1 | 5-Hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors | MERCK FROSST CANADA INC. (CA) | 1991-09-18 | — | — | EP | disclosed |