Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 13/20 | 0.75 |
| ▸ | CDK2 | P24941 | 13/20 | 0.75 |
| ▸ | CCNE2 | O96020 | 12/20 | 0.75 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.73 |
| ▸ | CDK5R1 | Q15078 | 6/20 | 0.73 |
| ▸ | CDK1 | P06493 | 3/20 | 0.73 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.73 |
| ▸ | PDE5A | O76074 | 1/20 | 0.73 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.73 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.73 |
| ▸ | CDK7 | P50613 | 1/20 | 0.73 |
| ▸ | CDK9 | P50750 | 1/20 | 0.73 |
| ▸ | CCNH | P51946 | 1/20 | 0.73 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.73 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.73 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.73 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3680752 | 0.95 | CCNE1 (0.82) | CCNE1CDK2CCNE2CDK5CDK5R1 | |
| SCHEMBL14071580 | 0.88 | CDK2 (0.85) | CCNE1CDK2CCNE2CDK5CDK5R1 | |
| SCHEMBL6143053 | 0.86 | CDK2 (1.00) | CCNE1CDK2CCNE2CDK5CDK5R1 | |
| SCHEMBL5828753 | 0.85 | CCNE2 (0.65) | CCNE1CDK2CCNE2CDK5CDK5R1 | |
| SCHEMBL1394958 | 0.84 | CCNE2 (1.00) | CCNE1CDK2CCNE2CDK5CDK5R1 | |
| SCHEMBL5827556 | 0.83 | CCNE2 (0.78) | CCNE1CDK2CCNE2CDK5CDK5R1 | |
| SCHEMBL2364042 | 0.82 | CDK1 (0.87) | CCNE1CDK2CCNE2CDK5CDK5R1 | |
| SCHEMBL4277404 | 0.81 | CDK1 (1.00) | CCNE1CDK2CCNE2CDK5CDK5R1 | |
| SCHEMBL5828592 | 0.79 | CCNE2 (0.70) | CCNE1CDK2CCNE2CDK5CDK5R1 | |
| SCHEMBL3679286 | 0.79 | CCNE1 (0.65) | CCNE1CDK2CCNE2CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150982-B1 | PURINE INHIBITORS OF CYCLIN DEPENDENT KINASE 2 AND IkB-alpha | CV THERAPEUTICS INC (US) | 2005-10-12 | — | — | EP | claimed |
| US-20020035252-A1 | Purine inhibitors of cyclin dependent kinase 2 & IkBa | LUM ROBERT T (US) | 2002-03-21 | — | — | US | claimed |
| US-7109330-B2 | Purine inhibitors of cyclin dependent kinase 2 and IκB-α | CV THERAPEUTICS, INC. (US) | 2006-09-19 | — | — | US | disclosed |
| EP-1150982-B1 | PURINE INHIBITORS OF CYCLIN DEPENDENT KINASE 2 AND IkB-alpha | CV THERAPEUTICS INC (US) | 2005-10-12 | — | — | EP | disclosed |
| US-20050080261-A1 | Purine inhibitors of cyclin dependent kinase 2 and IkappaB-alpha | LUM ROBERT T (US) | 2005-04-14 | — | — | US | disclosed |
| US-6790958-B2 | ANTIPROLIFERATIVE AGENTS; FUNGICIDES | LUM ROBERT T (US) | 2004-09-14 | — | — | US | disclosed |
| US-20020035252-A1 | Purine inhibitors of cyclin dependent kinase 2 & IkBa | LUM ROBERT T (US) | 2002-03-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050080261-A1 | Purine inhibitors of cyclin dependent kinase 2 and IkappaB-alpha | IKBKB, NFKB1, CDK4 | CCNE1 51/4885CDK2 5/4885CCNE2 65/4885 |
| US-20020035252-A1 | Purine inhibitors of cyclin dependent kinase 2 & IkBa | AURKB, CDKN1A, IKBKB | CCNE1 96/4885CDK2 8/4885CCNE2 202/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.