Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | PPID | Q08752 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9175373 | 0.93 | TK1 (0.44) | TK1ALDH1A1TSHRLMNASMN1; SMN2 | |
| SCHEMBL10776041 | 0.93 | TK1 (0.44) | TK1ALDH1A1TSHRLMNASMN1; SMN2 | |
| SCHEMBL9174666 | 0.89 | TK1 (0.43) | TK1ALDH1A1TSHRLMNASMN1; SMN2 | |
| SCHEMBL3837132 | 0.85 | TK1 (0.45) | TK1ALDH1A1LMNACTSKPOLB | |
| SCHEMBL5354077 | 0.85 | TK1 (0.45) | TK1ALDH1A1LMNACTSKPOLB | |
| SCHEMBL4926228 | 0.82 | TK1 (0.46) | TK1ALDH1A1TSHRLMNACTSK | |
| SCHEMBL4925573 | 0.82 | TK1 (0.46) | TK1ALDH1A1TSHRLMNACTSK | |
| SCHEMBL4191209 | 0.82 | TK1 (0.46) | TK1ALDH1A1TSHRLMNACTSK | |
| SCHEMBL3954890 | 0.79 | TK1 (0.44) | TK1ALDH1A1TSHRLMNASMN1; SMN2 | |
| SCHEMBL2131414 | 0.79 | TK1 (0.44) | TK1ALDH1A1TSHRLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE39333-E1 | Process for the preparation of 5-hydroxy-3-oxopentanoic acid derivatives | KANEKA CORPORATION (JP) | 2006-10-10 | — | — | US | disclosed |
| EP-1104750-B1 | PROCESSES FOR THE PREPARATION OF 5-HYDROXY-3-OXOPENTANOIC ACID DERIVATIVES | KANEKA CORP (JP) | 2004-04-14 | — | — | EP | disclosed |
| US-6340767-B1 | REACTION OF LITHIUM AMIDE WITH ACETIC ACID ESTER AND HYDROXY PROPIONIC ACID | KANEKA CORPORATION (JP) | 2002-01-22 | — | — | US | disclosed |
| EP-1104750-A1 | PROCESSES FOR THE PREPARATION OF 5-HYDROXY-3-OXOPENTANOIC ACID DERIVATIVES | KANEKA CORPORATION (JP) | 2001-06-06 | — | — | EP | disclosed |