Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | FLT3 | P36888 | 4/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5829170 | 1.00 | AXL (0.44) | AXLCA2FLT3PDGFRBLOXL2 | |
| SCHEMBL5828048 | 0.84 | FLT3 (0.51) | AXLCA2FLT3PDGFRBLOXL2 | |
| SCHEMBL5828046 | 0.84 | FLT3 (0.51) | AXLCA2FLT3PDGFRBLOXL2 | |
| SCHEMBL5828084 | 0.83 | AXL (0.50) | AXLCA2FLT3PDGFRBLOXL2 | |
| SCHEMBL5828082 | 0.83 | AXL (0.50) | AXLCA2FLT3PDGFRBLOXL2 | |
| SCHEMBL5829136 | 0.80 | AXL (0.50) | AXLCA2FLT3PDGFRBLOXL2 | |
| SCHEMBL5829134 | 0.80 | AXL (0.50) | AXLCA2FLT3PDGFRBLOXL2 | |
| SCHEMBL5828843 | 0.80 | CYP1A1 (0.46) | AXLFLT3PDGFRBLOXL2PDGFRA | |
| SCHEMBL5828840 | 0.80 | CYP1A1 (0.46) | AXLFLT3PDGFRBLOXL2PDGFRA | |
| SCHEMBL5827972 | 0.78 | AXL (0.50) | AXLCA2FLT3PDGFRBLOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7094798-B1 | Inhibitors of checkpoint kinases (Wee1 and Chk1) | PFIZER INC (US) | 2006-08-22 | — | — | US | disclosed |