Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 7/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.46 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5829134 | 1.00 | AXL (0.50) | AXLFLT3PDGFRBPDGFRALOXL2 | |
| SCHEMBL5828296 | 0.89 | NFE2L2 (0.55) | AXLFLT3PDGFRBPDGFRALOXL2 | |
| SCHEMBL5828295 | 0.89 | NFE2L2 (0.55) | AXLFLT3PDGFRBPDGFRALOXL2 | |
| SCHEMBL5827972 | 0.89 | AXL (0.50) | AXLFLT3PDGFRBPDGFRALOXL2 | |
| SCHEMBL5827969 | 0.89 | AXL (0.50) | AXLFLT3PDGFRBPDGFRALOXL2 | |
| SCHEMBL5829053 | 0.87 | CTSV (0.49) | AXLFLT3PDGFRBPDGFRAKDM4E | |
| SCHEMBL5829057 | 0.87 | CTSV (0.49) | AXLFLT3PDGFRBPDGFRAKDM4E | |
| SCHEMBL5828082 | 0.83 | AXL (0.50) | AXLFLT3PDGFRBPDGFRALOXL2 | |
| SCHEMBL5828084 | 0.83 | AXL (0.50) | AXLFLT3PDGFRBPDGFRALOXL2 | |
| SCHEMBL5828048 | 0.82 | FLT3 (0.51) | AXLFLT3PDGFRBPDGFRALOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7094798-B1 | Inhibitors of checkpoint kinases (Wee1 and Chk1) | PFIZER INC (US) | 2006-08-22 | — | — | US | disclosed |