Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSV | O60911 | 3/20 | 0.62 |
| ▸ | CTSL | P07711 | 3/20 | 0.62 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.62 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.49 |
| ▸ | TUBB | P07437 | 1/20 | 0.49 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.49 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.49 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.49 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.49 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.49 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.49 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.49 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.49 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.49 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7199353 | 0.95 | SRD5A2 (0.54) | CTSVCTSLSRD5A2SRD5A1MEN1 | |
| SCHEMBL12047200 | 0.80 | CTSV (0.68) | CTSVCTSLSRD5A2SRD5A1KMT2A | |
| SCHEMBL18975225 | 0.79 | SRD5A1 (0.60) | CTSVCTSLSRD5A2SRD5A1MEN1 | |
| SCHEMBL5504619 | 0.79 | KDM4E (0.69) | CTSVCTSLSRD5A2MEN1KMT2A | |
| SCHEMBL7255463 | 0.78 | CTSV (0.68) | CTSVCTSLSRD5A2SRD5A1MEN1 | |
| SCHEMBL1943022 | 0.78 | CTSV (0.68) | CTSVCTSLSRD5A2SRD5A1MEN1 | |
| SCHEMBL31564631 | 0.77 | PLK1 (0.49) | CTSVCTSLSRD5A2SRD5A1HPGD | |
| SCHEMBL3243291 | 0.77 | SRD5A2 (1.00) | CTSVCTSLSRD5A2SRD5A1MEN1 | |
| SCHEMBL7169748 | 0.77 | SRD5A2 (1.00) | CTSVCTSLSRD5A2SRD5A1MEN1 | |
| SCHEMBL7427808 | 0.76 | EDNRA (0.56) | SRD5A2SRD5A1MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7094798-B1 | Inhibitors of checkpoint kinases (Wee1 and Chk1) | PFIZER INC (US) | 2006-08-22 | — | — | US | disclosed |
| EP-1501831-A1 | INHIBITORS OF CHECKPOINT KINASES (WEE1 AND CHK1) | WARNER-LAMBERT COMPANY LLC (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003091255-A1 | INHIBITORS OF CHECKPOINT KINASES (WEE1 AND CHK1) | WARNER-LAMBERT COMPANY LLC (US) | 2003-11-06 | — | — | WO | disclosed |