Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL582860 | 0.93 | POLB (0.46) | POLBPDE4BPDE7AKMT2A | |
| Bicarbonate SCHEMBL583115 | 0.93 | POLB (0.46) | POLBPDE4BPDE7AADORA2AADORA2B | |
| Bicarbonate SCHEMBL583862 | 0.93 | POLB (0.46) | POLBPDE4BPDE7ARAB9ASMN1; SMN2 | |
| Bicarbonate SCHEMBL583229 | 0.92 | POLB (0.46) | POLBPDE4BPDE7ARAB9ASMN1; SMN2 | |
| SCHEMBL582541 | 0.92 | POLB (0.48) | POLBPDE4BPDE7ARAB9ASMN1; SMN2 | |
| Bicarbonate SCHEMBL583188 | 0.91 | POLB (0.50) | POLBPDE4BPDE7ARAB9ASMN1; SMN2 | |
| Bicarbonate SCHEMBL583789 | 0.91 | POLB (0.50) | POLBPDE4BPDE7ARAB9ASMN1; SMN2 | |
| Bicarbonate SCHEMBL583374 | 0.91 | POLB (0.50) | POLBPDE4BPDE7ARAB9ASMN1; SMN2 | |
| Bicarbonate SCHEMBL582582 | 0.90 | POLB (0.48) | POLBPDE4BPDE7ARAB9ASMN1; SMN2 | |
| Bicarbonate SCHEMBL583485 | 0.89 | POLB (0.47) | POLBPDE4BPDE7ARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124944-B1 | Pyrazolo[3,4-b]pyridine derivatives as phosphodiesterase inhibitors | RANBAXY LAB LTD (IN) | 2012-02-15 | — | — | EP | claimed |