Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 11/20 | 0.52 |
| ▸ | NPC1 | O15118 | 10/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.52 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 5/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 5/20 | 0.51 |
| ▸ | RELA | Q04206 | 5/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.49 |
| ▸ | MGAM | O43451 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12043742 | 0.82 | HDAC8 (0.65) | HDAC8MAPTALDH1A1GAARAB9A | |
| SCHEMBL8742431 | 0.80 | ALDH1A1 (0.54) | HDAC8MAPTALDH1A1GAARAB9A | |
| SCHEMBL23722728 | 0.79 | HDAC8 (0.56) | HDAC8MAPTALDH1A1GAARAB9A | |
| SCHEMBL6313523 | 0.79 | HDAC8 (0.56) | HDAC8MAPTALDH1A1GAARAB9A | |
| SCHEMBL6446563 | 0.79 | HDAC8 (0.56) | HDAC8MAPTALDH1A1GAARAB9A | |
| SCHEMBL15459285 | 0.79 | HDAC8 (0.56) | HDAC8MAPTALDH1A1GAARAB9A | |
| SCHEMBL13127973 | 0.78 | HDAC8 (0.59) | HDAC8MAPTALDH1A1GAARAB9A | |
| SCHEMBL24802521 | 0.78 | HDAC8 (0.55) | HDAC8MAPTALDH1A1GAARAB9A | |
| SCHEMBL6443604 | 0.76 | ALDH1A1 (0.58) | HDAC8MAPTALDH1A1GAARAB9A | |
| SCHEMBL7392749 | 0.76 | ALDH1A1 (0.58) | HDAC8MAPTALDH1A1GAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2670774-A1 | CASPASE-2 INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2013-12-11 | — | — | EP | disclosed |
| WO-2012104224-A1 | CASPASE-2 INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2012-08-09 | — | — | WO | disclosed |
| EP-1626732-A2 | MEANS FOR PREVENTING AND TREATING CELLULAR DEATH AND THEIR BIOLOGICAL APPLICATIONS | Theraptosis S.A. (FR) | 2006-02-22 | — | — | EP | disclosed |
| WO-2004103389-A2 | MEANS FOR PREVENTING AND TREATING CELLULAR DEATH AND THEIR BIOLOGICAL APPLICATIONS | THERAPTOSIS SA (FR) | 2004-12-02 | — | — | WO | disclosed |