Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.51 |
| ▸ | PDE6C | P51160 | 1/20 | 0.48 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5831080 | 0.97 | PDE5A (0.54) | PDE5APDE6CPDE11A | |
| SCHEMBL5830586 | 0.92 | PDE5A (0.59) | PDE5A | |
| SCHEMBL5830162 | 0.91 | PDE5A (0.54) | PDE5A | |
| SCHEMBL5830283 | 0.89 | PDE5A (0.56) | PDE5A | |
| SCHEMBL5827907 | 0.87 | PDE5A (0.65) | PDE5APDE6CPDE11A | |
| SCHEMBL5830233 | 0.86 | PDE5A (0.52) | PDE5APDE6CPDE11A | |
| SCHEMBL5262294 | 0.86 | PDE5A (0.52) | PDE5APDE6CPDE11A | |
| SCHEMBL6311874 | 0.86 | PDE5A (0.61) | PDE5APDE6CPDE11A | |
| SCHEMBL5261816 | 0.85 | PDE5A (0.51) | PDE5APDE6CPDE11A | |
| SCHEMBL5263935 | 0.85 | PDE5A (0.41) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060824-B2 | Pyrrolotriazolopyrimidinone derivatives | ALMIRALL PRODESFARMA, S.A. (ES) | 2006-06-13 | — | — | US | disclosed |