Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.58 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.58 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.49 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.49 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.49 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.40 |
| ▸ | CDK1 | P06493 | 4/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.40 |
| ▸ | GSK3B | P49841 | 3/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | CDK9 | P50750 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7003835 | 1.00 | BRD4 (0.58) | BRD4CREBBPABL1OPRM1OPRL1 | |
| SCHEMBL5830609 | 0.86 | PIP4K2A (0.51) | BRD4CREBBPABL1OPRM1OPRL1 | |
| SCHEMBL19145392 | 0.83 | ABL1 (0.54) | BRD4CREBBPABL1OPRM1OPRL1 | |
| SCHEMBL19105603 | 0.80 | PIP4K2A (0.49) | BRD4CREBBPABL1OPRM1OPRL1 | |
| SCHEMBL5829804 | 0.77 | CYP11B1 (0.55) | ABL1PIP4K2APIP4K2BJAK2CCNB2 | |
| SCHEMBL5830094 | 0.77 | PIP4K2A (0.56) | ABL1OPRM1OPRL1PIP4K2APIP4K2B | |
| SCHEMBL16090379 | 0.76 | BRD4 (0.52) | BRD4CREBBPABL1OPRM1OPRL1 | |
| SCHEMBL5843496 | 0.76 | JAK2 (0.51) | BRD4CREBBPABL1OPRM1OPRL1 | |
| SCHEMBL10712645 | 0.75 | TDP2 (0.52) | ABL1PIP4K2APIP4K2BJAK2LRRK2 | |
| SCHEMBL6324288 | 0.75 | CCNB2 (0.49) | ABL1PIP4K2APIP4K2BJAK2CCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7053086-B2 | 4-heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors | SUGEN, INC. (US) | 2006-05-30 | — | — | US | disclosed |
| US-20040097497-A1 | 4-heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors | SUGEN, INC. | 2004-05-20 | — | — | US | disclosed |
| US-6635640-B2 | 4-heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors | SUGEN, INC. | 2003-10-21 | — | — | US | disclosed |
| EP-1296975-A1 | 4-HETEROARYL-3-HETEROARYLIDENYL-2-INDOLINONES AND THEIR USE AS PROTEIN KINASE INHIBITORS | Sugen, Inc. (US) | 2003-04-02 | — | — | EP | disclosed |
| US-20020187978-A1 | 4-Heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors | SUGEN, INC. | 2002-12-12 | — | — | US | disclosed |
| WO-2002002551-A1 | 4-HETEROARYL-3-HETEROARYLIDENYL-2-INDOLINONES AND THEIR USE AS PROTEIN KINASE INHIBITORS | SUGEN, INC. (US) | 2002-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020187978-A1 | 4-Heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors | CDK2, CDK20, CDK3 | BRD4 681/4885CREBBP 1096/4885ABL1 243/4885 |
| US-20040097497-A1 | 4-heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors | CDK2, CDK20, CDK3 | BRD4 681/4885CREBBP 1096/4885ABL1 243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.