Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.51 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CCKBR | P32239 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.37 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | TYMS | P04818 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | VDR | P11473 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5831838 | 0.94 | HSD11B1 (0.55) | HSD11B1KMT2ACCKBRNPC1RAB9A | |
| SCHEMBL5830800 | 0.89 | HSD11B1 (0.51) | HSD11B1SLC2A2KMT2ANPC1RAB9A | |
| SCHEMBL5830646 | 0.88 | HSD11B1 (0.50) | HSD11B1KMT2ANPC1RAB9AMAPK1 | |
| SCHEMBL5830689 | 0.83 | HSD11B1 (0.71) | HSD11B1KMT2ASMN1; SMN2MAPTHSD17B1 | |
| SCHEMBL5831705 | 0.81 | MAPT (0.52) | HSD11B1SLC2A2KMT2ANPC1RAB9A | |
| SCHEMBL5831502 | 0.80 | HSD11B1 (0.58) | HSD11B1CCKBRHSD17B1HSD17B2KDM4E | |
| SCHEMBL6623144 | 0.80 | HSD11B1 (0.49) | HSD11B1CCKBRHSD17B1HSD17B2KDM4E | |
| SCHEMBL5830740 | 0.80 | HSD11B1 (0.46) | HSD11B1KMT2AMAPK1MAPTLMNA | |
| SCHEMBL5830857 | 0.79 | HSD11B1 (0.62) | HSD11B1KMT2ARAB9ASMN1; SMN2HSD17B1 | |
| SCHEMBL5831048 | 0.79 | HSD11B1 (0.59) | HSD11B1KMT2ARAB9AMAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7074788-B2 | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 | BIOVITRUM AB (SE) | 2006-07-11 | — | — | US | claimed |