SCHEMBL5833448

SCHEMBL5833448

O=C(O)c1cc2cc(N(Cc3ccccc3)Cc3ccccc3)ncc2[nH]1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR3 P49019 4/20 0.58
SRD5A2 P31213 4/20 0.50
KDM4E B2RXH2 2/20 0.50
HPGD P15428 2/20 0.50
HSD17B10 Q99714 2/20 0.50
ALDH1A1 P00352 1/20 0.50
CYP1A2 P05177 1/20 0.50
CYP2C9 P11712 1/20 0.50
SRD5A1 P18405 1/20 0.49
MAPT P10636 1/20 0.47
DAO P14920 1/20 0.47
HCAR2 Q8TDS4 1/20 0.45
RXFP1 Q9HBX9 1/20 0.44
ATM Q13315 1/20 0.44
GPR35 Q9HC97 1/20 0.43
KMT2A Q03164 2/20 0.42
MEN1 O00255 1/20 0.42
CA12 O43570 1/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4271610 0.90 HCAR3 (0.49) HCAR3SRD5A2KDM4EHPGDHSD17B10
SCHEMBL4268248 0.89 MEN1 (0.48) HCAR3SRD5A2KDM4EHPGDHSD17B10
SCHEMBL13660717 0.85 HCAR3 (0.43) HCAR3SRD5A2KDM4EHPGDHSD17B10
SCHEMBL4266823 0.85 KDM4E (0.58) HCAR3KDM4EHPGDHSD17B10ALDH1A1
SCHEMBL4267461 0.81 HCAR3 (0.43) HCAR3ALDH1A1
SCHEMBL4267874 0.80 CYP2A6 (0.44) HCAR3KDM4EALDH1A1MAPTHCAR2
SCHEMBL4279641 0.79 MEN1 (0.39) HCAR3SRD5A2KDM4EHPGDHSD17B10
Hydrochloric Acid SCHEMBL4267002 0.79 HCAR3 (0.38) HCAR3SRD5A2KDM4EHPGDHSD17B10
Hydrochloric Acid SCHEMBL4279634 0.79 HCAR3 (0.38) HCAR3SRD5A2KDM4EHPGDHSD17B10
SCHEMBL4275766 0.78 HCAR3 (0.40) HCAR3KDM4EALDH1A1CYP2C9MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1732566-A2 6-AZAINDOLE COMPOUND Takeda Pharmaceutical Company Limited (JP) 2006-12-20 EP disclosed
WO-2005097129-A2 6-AZAINDOLE COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2005-10-20 WO disclosed