Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TNNI3K | Q59H18 | 4/20 | 0.46 |
| ▸ | EGFR | P00533 | 8/20 | 0.43 |
| ▸ | TERT | O14746 | 2/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL374274 | 0.80 | TNNI3K (0.53) | TNNI3KEGFRMEN1NPC1RAB9A | |
| SCHEMBL374544 | 0.80 | TNNI3K (0.48) | KDM4EPOLBMAPTMAPK1TNNI3K | |
| SCHEMBL374315 | 0.73 | TNNI3K (0.51) | TNNI3KEGFRCDK2MEN1NPC1 | |
| SCHEMBL27523685 | 0.73 | EGFR (0.51) | KDM4EPOLBMAPTMAPK1EGFR | |
| SCHEMBL16136713 | 0.73 | TERT (0.54) | TERTCCNA2CDK2 | |
| Hydrochloric Acid SCHEMBL29778291 | 0.72 | TERT (0.52) | TERTCCNA2CDK2 | |
| SCHEMBL374904 | 0.71 | TNNI3K (0.57) | TNNI3KEGFRMEN1NPC1RAB9A | |
| SCHEMBL11983511 | 0.70 | TERT (0.51) | KDM4EMAPK1TERTCCNA2CDK2 | |
| SCHEMBL27208120 | 0.69 | TERT (0.50) | TERTMAP4K4CCNA2CDK2 | |
| SCHEMBL374504 | 0.69 | EGFR (0.64) | KDM4EMAPK1TNNI3KEGFRJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2418205-A1 | Pyrimidine urea derivatives as kinase inhibitors | Novartis AG (CH) | 2012-02-15 | — | — | EP | disclosed |