Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL737249 | 0.92 | TDP1 (0.43) | TDP1MAPK1HSD17B10LMNATSHR | |
| SCHEMBL3796517 | 0.83 | TDP1 (0.52) | TDP1MAPK1HSD17B10LMNA | |
| SCHEMBL16508366 | 0.80 | TDP1 (0.43) | TDP1MAPK1HSD17B10LMNATSHR | |
| SCHEMBL15780471 | 0.80 | TDP1 (0.43) | TDP1MAPK1HSD17B10LMNATSHR | |
| SCHEMBL19263925 | 0.80 | TDP1 (0.43) | TDP1MAPK1HSD17B10LMNATSHR | |
| SCHEMBL9419450 | 0.80 | LMNA (0.38) | TDP1MAPK1LMNATSHR | |
| SCHEMBL16093255 | 0.80 | LMNA (0.38) | TDP1MAPK1LMNATSHR | |
| Propylene Glycol SCHEMBL8927832 | 0.79 | TDP1 (0.56) | TDP1MAPK1HSD17B10LMNATSHR | |
| Propylene Glycol SCHEMBL412141 | 0.77 | TDP1 (0.53) | TDP1MAPK1HSD17B10LMNATSHR | |
| SCHEMBL10866121 | 0.76 | LMNA (0.43) | TDP1MAPK1HSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6989107-B1 | Mechanical working in the presence of a multi-purpose cooling lubricant | AB CHEM DIMENSION (SE) | 2006-01-24 | — | — | US | disclosed |