Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL737250 | 0.96 | TDP1 (0.38) | TDP1TSHRHSD17B10USP2 | |
| SCHEMBL1957694 | 0.91 | TDP1 (0.39) | TDP1TSHRUSP2 | |
| SCHEMBL9995061 | 0.86 | TSHR (0.37) | TDP1TSHRUSP2 | |
| Acetic Acid SCHEMBL28017937 | 0.86 | TDP1 (0.32) | TDP1 | |
| SCHEMBL12517107 | 0.81 | TDP1 (0.40) | TDP1TSHRHSD17B10 | |
| Propylene Glycol SCHEMBL412141 | 0.81 | TDP1 (0.53) | TDP1TSHRHSD17B10 | |
| SCHEMBL2353818 | 0.81 | TDP1 (0.40) | TDP1TSHRHSD17B10 | |
| SCHEMBL4440314 | 0.81 | LMNA (0.40) | TDP1TSHRUSP2 | |
| SCHEMBL9995078 | 0.81 | USP2 (0.40) | USP2 | |
| Glycerin SCHEMBL28081742 | 0.80 | TDP1 (0.46) | TDP1HSD17B10USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6989107-B1 | Mechanical working in the presence of a multi-purpose cooling lubricant | AB CHEM DIMENSION (SE) | 2006-01-24 | — | — | US | disclosed |