Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 14/20 | 0.36 |
| ▸ | RAF1 | P04049 | 10/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.32 |
| ▸ | KDR | P35968 | 2/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.32 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5834112 | 0.90 | BRAF (0.36) | BRAFRAF1EGFRKDR | |
| SCHEMBL2890231 | 0.82 | BRAF (0.53) | BRAFRAF1KDR | |
| SCHEMBL5834166 | 0.81 | BRAF (0.42) | BRAFRAF1EGFRERBB2 | |
| SCHEMBL2893684 | 0.80 | BRAF (0.54) | BRAFRAF1KDR | |
| SCHEMBL2891466 | 0.77 | BRAF (0.46) | BRAFRAF1KDR | |
| SCHEMBL2891332 | 0.75 | BRAF (0.54) | BRAFRAF1KDR | |
| SCHEMBL2886003 | 0.73 | RAF1 (0.51) | BRAFRAF1KDR | |
| SCHEMBL2893790 | 0.73 | RAF1 (0.63) | BRAFRAF1KDR | |
| SCHEMBL2893998 | 0.73 | RAF1 (0.51) | BRAFRAF1KDR | |
| SCHEMBL5834168 | 0.72 | RAF1 (0.47) | BRAFRAF1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7071216-B2 | Substituted benz-azoles and methods of their use as inhibitors of Raf kinase | CHIRON CORPORATION (US) | 2006-07-04 | — | — | US | disclosed |