Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 10/20 | 0.36 |
| ▸ | RAF1 | P04049 | 6/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.34 |
| ▸ | CCR4 | P51679 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 4/20 | 0.33 |
| ▸ | NPY1R | P25929 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.32 |
| ▸ | FLT4 | P35916 | 1/20 | 0.32 |
| ▸ | TEK | Q02763 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5833708 | 0.90 | BRAF (0.36) | BRAFRAF1KDREGFR | |
| SCHEMBL2891466 | 0.88 | BRAF (0.46) | BRAFRAF1KDR | |
| SCHEMBL2890231 | 0.83 | BRAF (0.53) | BRAFRAF1KDR | |
| SCHEMBL2893684 | 0.81 | BRAF (0.54) | BRAFRAF1KDR | |
| SCHEMBL3010935 | 0.77 | BRAF (0.51) | BRAFRAF1KDR | |
| SCHEMBL2891332 | 0.76 | BRAF (0.54) | BRAFRAF1KDR | |
| SCHEMBL3011329 | 0.73 | BRAF (0.50) | BRAFRAF1P2RX3KDR | |
| SCHEMBL2887038 | 0.72 | BRAF (0.46) | BRAFRAF1KDR | |
| SCHEMBL2891111 | 0.72 | P2RX3 (0.55) | BRAFRAF1P2RX3 | |
| SCHEMBL2891705 | 0.72 | RAF1 (0.64) | BRAFRAF1P2RX3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7071216-B2 | Substituted benz-azoles and methods of their use as inhibitors of Raf kinase | CHIRON CORPORATION (US) | 2006-07-04 | — | — | US | disclosed |