Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 9/20 | 0.43 |
| ▸ | MAOB | P27338 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | CALML3 | P27482 | 1/20 | 0.36 |
| ▸ | SDHA | P31040 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 9/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6765989 | 0.87 | MAOA (0.38) | MAOAMAOBLMNAPTGS1CALML3 | |
| SCHEMBL5845072 | 0.86 | MAOA (0.36) | MAOAMAOBLMNAPTGS1CALML3 | |
| SCHEMBL5834248 | 0.85 | MAOA (0.49) | MAOAMAOBLMNAPTGS1CALML3 | |
| SCHEMBL6765854 | 0.85 | CYP2E1 (0.35) | MAOAMAOBLMNAPTGS1CALML3 | |
| SCHEMBL6772076 | 0.85 | F10 (0.35) | MAOAMAOBLMNAPTGS1CALML3 | |
| SCHEMBL6762885 | 0.83 | MAOA (0.35) | MAOAMAOBLMNAPTGS1CALML3 | |
| SCHEMBL5833627 | 0.83 | F10 (0.35) | MAOAMAOBLMNAPTGS1CALML3 | |
| SCHEMBL5834079 | 0.83 | CALML3 (0.37) | MAOAMAOBLMNAPTGS1CALML3 | |
| SCHEMBL5834266 | 0.83 | MAOA (0.35) | MAOAMAOBLMNAPTGS1CALML3 | |
| SCHEMBL4017272 | 0.81 | MAOA (0.51) | MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7087629-B2 | Useful activity against Gram-positive pathogens and, in particular, against various strains exhibiting resistance to vancomycin and against E. faecium strains resistant to both aminoglycosides and clinically used beta-lactams | ASTRAZENECA AB (SE) | 2006-08-08 | — | — | US | disclosed |
| US-6734200-B1 | ANTIBIOTIC COMPOUNDS CONTAINING A SUBSTITUTED OXAZOLIDINONE RING; ACTIVITY AGAINST GRAM-POSITIVE PATHOGENS | ASTRAZENECA AB (SE) | 2004-05-11 | — | — | US | disclosed |