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Sugi Predict / Compounds / SCHEMBL5833969

SCHEMBL5833969

SCHEMBL5833969

Cc1cc(N(C[C@H]2CN(c3cc(F)c(C4=CCN(C(=O)[C@@H]5COC(C)(C)O5)CC4)c(F)c3)C(=O)O2)C(=O)OC(C)(C)C)on1

nearest known ligand 0.36

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ MAOA P21397 6/20 0.36
▸ MAOB P27338 2/20 0.34
▸ F10 P00742 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5833776 0.89 MAOB (0.36) MAOAMAOBF10
SCHEMBL5834193 0.89 MAOB (0.36) MAOAMAOBF10
SCHEMBL5833640 0.87 MAOB (0.34) MAOAMAOBF10
SCHEMBL5834009 0.87 MAOB (0.34) MAOAMAOBF10
SCHEMBL5833993 0.86 MAOB (0.34) MAOAMAOBF10
SCHEMBL5833798 0.86 MAOB (0.34) MAOAMAOBF10
SCHEMBL5834205 0.86 MAOB (0.35) MAOAMAOBF10
SCHEMBL5833336 0.81 CALML3 (0.40) MAOAMAOB
SCHEMBL5833669 0.79 MAOA (0.40) MAOAMAOBF10
SCHEMBL5833988 0.79 MAOA (0.35) MAOAMAOBF10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7087629-B2 Useful activity against Gram-positive pathogens and, in particular, against various strains exhibiting resistance to vancomycin and against E. faecium strains resistant to both aminoglycosides and clinically used beta-lactams ASTRAZENECA AB (SE) 2006-08-08 — — US disclosed
US-6734200-B1 ANTIBIOTIC COMPOUNDS CONTAINING A SUBSTITUTED OXAZOLIDINONE RING; ACTIVITY AGAINST GRAM-POSITIVE PATHOGENS ASTRAZENECA AB (SE) 2004-05-11 — — US disclosed