Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.71 |
| ▸ | NPC1 | O15118 | 7/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.71 |
| ▸ | MAPT | P10636 | 3/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.58 |
| ▸ | RELA | Q04206 | 1/20 | 0.58 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.56 |
| ▸ | CDK2 | P24941 | 3/20 | 0.56 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.56 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.56 |
| ▸ | CDK1 | P06493 | 1/20 | 0.56 |
| ▸ | CDK4 | P11802 | 1/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.56 |
| ▸ | CCND1 | P24385 | 1/20 | 0.56 |
| ▸ | CDK7 | P50613 | 1/20 | 0.56 |
| ▸ | CDK9 | P50750 | 1/20 | 0.56 |
| ▸ | CCNH | P51946 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10016466 | 0.83 | ALDH1A1 (1.00) | RAB9ANPC1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL5836025 | 0.83 | ALDH1A1 (0.68) | RAB9ANPC1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL5836292 | 0.79 | CCNE1 (0.62) | RAB9ANPC1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL6282337 | 0.78 | CDK2 (0.62) | RAB9ANPC1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL5835908 | 0.74 | CCNE1 (0.53) | RAB9ANPC1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL5835693 | 0.74 | CCNE1 (0.55) | RAB9ANPC1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL5835846 | 0.74 | ALDH1A1 (0.55) | RAB9ANPC1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL5835512 | 0.73 | CCNE1 (0.67) | ALDH1A1SMN1; SMN2CCNE1CDK2CDK5 | |
| SCHEMBL5836595 | 0.73 | ALDH1A1 (0.70) | RAB9ANPC1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL11330935 | 0.72 | ALDH1A1 (0.64) | RAB9ANPC1ALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037929-B1 | 2-amino-thiazole derivatives, process for their preparation, and their use as antitumor agents | PHARMACIA & UPJOHN S.P.A. (IT) | 2006-05-02 | — | — | US | claimed |
| CN-1325389-A | 2-aminothiazole derivatives, process for preparing the same and their use as antitumor agents | PHARMACIA & UPJOHN SPA (IT) | 2001-12-05 | — | — | CN | claimed |
| US-7037929-B1 | 2-amino-thiazole derivatives, process for their preparation, and their use as antitumor agents | PHARMACIA & UPJOHN S.P.A. (IT) | 2006-05-02 | — | — | US | disclosed |
| CN-1325389-A | 2-aminothiazole derivatives, process for preparing the same and their use as antitumor agents | PHARMACIA & UPJOHN SPA (IT) | 2001-12-05 | — | — | CN | disclosed |