Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.61 |
| ▸ | CDK2 | P24941 | 4/20 | 0.61 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.61 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.61 |
| ▸ | CDK1 | P06493 | 1/20 | 0.61 |
| ▸ | CDK4 | P11802 | 1/20 | 0.61 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.61 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.61 |
| ▸ | CCND1 | P24385 | 1/20 | 0.61 |
| ▸ | CDK7 | P50613 | 1/20 | 0.61 |
| ▸ | CDK9 | P50750 | 1/20 | 0.61 |
| ▸ | CCNH | P51946 | 1/20 | 0.61 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.61 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | GLS | O94925 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20588602 | 0.82 | GLS (0.59) | ALDH1A1GLSMAPTLMNAKDM4E | |
| SCHEMBL4161615 | 0.81 | GLS (0.58) | ALDH1A1CDK2SMN1; SMN2GLSMAPT | |
| SCHEMBL5836020 | 0.80 | CCNE1 (0.67) | ALDH1A1CCNE1CDK2CDK5CCNT1 | |
| SCHEMBL5835897 | 0.78 | CDK2 (0.64) | ALDH1A1CCNE1CDK2CDK5CCNT1 | |
| SCHEMBL5835961 | 0.78 | CCNE1 (0.70) | ALDH1A1CCNE1CDK2CDK5CCNT1 | |
| SCHEMBL5835546 | 0.78 | CCNE1 (0.70) | ALDH1A1CCNE1CDK2CDK5CCNT1 | |
| SCHEMBL5836172 | 0.78 | CDK2 (0.70) | ALDH1A1CCNE1CDK2CDK5CCNT1 | |
| SCHEMBL5835623 | 0.77 | MAPT (0.74) | ALDH1A1CCNE1CDK2CDK5CCNT1 | |
| SCHEMBL1535301 | 0.77 | CCNE1 (1.00) | ALDH1A1CCNE1CDK2CDK5CCNT1 | |
| SCHEMBL24917111 | 0.76 | KMT2A (0.69) | ALDH1A1CDK5CDK7CDK9SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037929-B1 | 2-amino-thiazole derivatives, process for their preparation, and their use as antitumor agents | PHARMACIA & UPJOHN S.P.A. (IT) | 2006-05-02 | — | — | US | claimed |
| EP-1124810-B9 | 2-AMINO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-12-28 | — | — | EP | claimed |
| EP-1124810-B1 | 2-AMINO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-05-04 | — | — | EP | claimed |
| CN-1325389-A | 2-aminothiazole derivatives, process for preparing the same and their use as antitumor agents | PHARMACIA & UPJOHN SPA (IT) | 2001-12-05 | — | — | CN | claimed |
| US-7037929-B1 | 2-amino-thiazole derivatives, process for their preparation, and their use as antitumor agents | PHARMACIA & UPJOHN S.P.A. (IT) | 2006-05-02 | — | — | US | disclosed |
| CN-1325389-A | 2-aminothiazole derivatives, process for preparing the same and their use as antitumor agents | PHARMACIA & UPJOHN SPA (IT) | 2001-12-05 | — | — | CN | disclosed |