Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 3/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | FDPS | P14324 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5835878 | 1.00 | CDK2 (0.46) | CDK2CCNE1CDK5SMN1; SMN2MAPK10 | |
| SCHEMBL5835804 | 0.83 | CDK2 (0.52) | CDK2CCNE1CDK5SMN1; SMN2MAPK10 | |
| SCHEMBL5835540 | 0.79 | CDK2 (0.50) | CDK2CCNE1CDK5SMN1; SMN2MAPK10 | |
| SCHEMBL5835873 | 0.76 | CDK2 (0.50) | CDK2CCNE1CDK5SMN1; SMN2MAPK10 | |
| SCHEMBL5835990 | 0.75 | CDK2 (0.49) | CDK2CCNE1CDK5SMN1; SMN2MAPK10 | |
| SCHEMBL5835971 | 0.75 | CDK2 (0.49) | CDK2CCNE1CDK5SMN1; SMN2MAPK10 | |
| SCHEMBL5836037 | 0.74 | CCNE1 (0.54) | CDK2CCNE1CDK5SMN1; SMN2MAPK10 | |
| SCHEMBL5835886 | 0.74 | CDK2 (0.43) | CDK2CCNE1CDK5SMN1; SMN2MAPK10 | |
| SCHEMBL15581413 | 0.73 | SMN1; SMN2 (0.51) | CDK2CCNE1CDK5SMN1; SMN2MAPK10 | |
| SCHEMBL5835799 | 0.73 | SMN1; SMN2 (0.51) | CDK2CCNE1CDK5SMN1; SMN2MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037929-B1 | 2-amino-thiazole derivatives, process for their preparation, and their use as antitumor agents | PHARMACIA & UPJOHN S.P.A. (IT) | 2006-05-02 | — | — | US | disclosed |
| EP-1124810-A1 | 2-AMINO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2001-08-22 | — | — | EP | disclosed |
| WO-2000026202-A1 | 2-AMINO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-05-11 | — | — | WO | disclosed |