Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 2/20 | 0.54 |
| ▸ | CDK2 | P24941 | 2/20 | 0.54 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | FDPS | P14324 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GLS | O94925 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5835540 | 0.84 | CDK2 (0.50) | CCNE1CDK2CDK5MAPK10SMN1; SMN2 | |
| SCHEMBL5835990 | 0.83 | CDK2 (0.49) | CCNE1CDK2CDK5MAPK10SMN1; SMN2 | |
| SCHEMBL5835804 | 0.81 | CDK2 (0.52) | CCNE1CDK2CDK5MAPK10SMN1; SMN2 | |
| SCHEMBL5835873 | 0.79 | CDK2 (0.50) | CCNE1CDK2CDK5MAPK10SMN1; SMN2 | |
| SCHEMBL5835971 | 0.78 | CDK2 (0.49) | CCNE1CDK2CDK5MAPK10SMN1; SMN2 | |
| SCHEMBL5835799 | 0.76 | SMN1; SMN2 (0.51) | CCNE1CDK2CDK5MAPK10SMN1; SMN2 | |
| SCHEMBL15581413 | 0.76 | SMN1; SMN2 (0.51) | CCNE1CDK2CDK5MAPK10SMN1; SMN2 | |
| SCHEMBL5835874 | 0.74 | CDK2 (0.46) | CCNE1CDK2CDK5MAPK10SMN1; SMN2 | |
| SCHEMBL5835878 | 0.74 | CDK2 (0.46) | CCNE1CDK2CDK5MAPK10SMN1; SMN2 | |
| SCHEMBL5835886 | 0.74 | CDK2 (0.43) | CCNE1CDK2CDK5MAPK10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1325389-A | 2-aminothiazole derivatives, process for preparing the same and their use as antitumor agents | PHARMACIA & UPJOHN SPA (IT) | 2001-12-05 | — | — | CN | claimed |
| US-7037929-B1 | 2-amino-thiazole derivatives, process for their preparation, and their use as antitumor agents | PHARMACIA & UPJOHN S.P.A. (IT) | 2006-05-02 | — | — | US | disclosed |
| CN-1325389-A | 2-aminothiazole derivatives, process for preparing the same and their use as antitumor agents | PHARMACIA & UPJOHN SPA (IT) | 2001-12-05 | — | — | CN | disclosed |